Last Updated on July 17, 2021 by Dr Sanusi Umar MD


In 2016, a peer-reviewed medical journal called Clinical, Cosmetic and Investigational Dermatology published a review on cohesive polydensified matrix hyaluronic acid fillers, displaying distinct viscoelastic properties, allowing for better integration even more distribution [1].  The review focused on different variations of Belotero, which is produced using CPM cross-linking technology. These individual variations differ according to hyaluronic acid concentrations ranging from 18-26mg/mL. 

They include Belotero Basic, Balance, Soft, Intense, Volume, and Hydro. The review also assessed the literature on comparable HA dermal fillers produced with cohesive polydensified cross-linking, Esthélis®, Mesolis®, Fortélis®, Modélis®.

The objective of this paper was to review clinical findings on these fillers in terms of safety, tolerability, and efficacy for skin rejuvenation and the augmentation of soft tissue.  

The review authors concluded that these newer forms of hyaluronic acid dermal fillers demonstrated good long-term tolerability, positive results, and an excellent safety profile. 

In spring 2019, Merz, the makers of Belotero, released a new version of the product line, Belotero Revive, containing both hyaluronic acid and glycerol. This new variation is designed to help patients address the first signs of aging and improve the skin’s elasticity.

Los Angeles Patient Chooses Belotero for the Elevens

Belotero is a hyaluronic acid (HA) filler specially designed to fill in fine line wrinkles close to the skin’s surface. It offers an excellent alternative to Botox for patients who wish to ease the appearance of etched lines without using a neuromuscular injection. This patient from Manhattan Beach, Los Angeles, is one such example. She wanted to eliminate the 11 lines between her brows and the horizontal creases on her forehead. Instead of Botox, Dysport, or Xeomin, she opted for a treatment performed by Dr. U, using Belotero for forehead wrinkles.

Best Non-Surgical Cheek Lift and Under Eye Hollow Correction in Los Angeles

To learn more about this patient case, visit: patient came to Dr. U seeking a non-s…

The Benefits of Belotero for Forehead Lines and Other Wrinkles

Belotero is state-of-the-art among existing hyaluronic acid fillers. Older HA injections tend to form clumps and are unsuitable for surface lines. They require much deeper injections.

By contrast, doctors can inject Belotero closer to the surface. As the first of its kind, Belotero is manufactured using proprietary CPM™ (Cohesive Polydensified Matrix) technology. This technique cross-links HA molecules together into a smooth and continuous substance.

The end Belotero product is capable of being more evenly distributed where injected. It creates a more seamless transition between treated and untreated areas.

Belotero continues to offer the primary benefits of hyaluronic acid, making it an excellent choice for etched lines on aging skin. HA hydrates moisturize and plump the skin by absorbing water and expanding three or four times its original size.

HA supports healthy and youthful levels of collagen, helping this tissue retain moisture and elastic properties.

What Are The Differences Between Belotero and Juvederm

As a filler with a hyaluronic acid base, people often wonder how Belotero differs from Juvederm, another HA filler. Density Belotero has a much lower density compared to Juvederm. Thus it is more ideal for filling in finer surface lines. Juvederm, on the other hand is injected much deeper into the skin. Its density is better suited for more advanced and severe folds and wrinkles. On average, Belotero results last between 6-12 months. However, this depends on what product is used. Juvederm, on the other hand, can last up to two years, depending on the product type.

Patient’s Photos Before  Dr. U’s Belotero Treatment for Forehead Furrows


Manhattan Beach patient hopes for improvement using Belotero for forehead wrinkles

Manhattan Beach patient hopes for improvement using Belotero for forehead wrinkles.

Manhattan Beach, Los Angeles patient wants to get rid of frown lines with Belotero.

Manhattan Beach, Los Angeles patient, wants to get rid of frown lines with Belotero.

The patient was unhappy with the appearance of etched lines on her forehead. The thought of them becoming worse over time worried her.

Dynamic wrinkles appeared when she raised her brows or furrowed them together, but she was primarily concerned with addressing the static resting lines in her upper face.

Belotero works to fill these creases in. As a hyaluronic acid, it helps rejuvenate the skin’s elasticity and ability to bounce back. It counters the effects of moisture loss in older skin as well as aging collagen tissue.

Belotero versus Other Hyaluronic Acid Fillers

Cross-linking technology makes each hyaluronic acid brand unique. This connects the HA molecules. Individual methods produce differences in clinical properties:

  • Size of HA particles
  • Degree of cross-linkage
  • Concentration

Classification of HA Fillers

Belotero is classified as a monophasic HA filler. Cross-linking and overall processing require only one step. While Juvederm is also monophasic, it isn’t the same as Belotero. Double cross-linked strands form long, continuous molecules of hyaluronic acid. Smaller HA particles branch off from these main units.

 Patients can rely on Belotero for forehead lines and many other objectives. Image - Merz

Patients can rely on Belotero for forehead lines and many other objectives. Image – Merz

Restylane and Perlane (now known as Restylane Lyft ™) are classified as biphasic fillers, requiring two phases. Particle clusters of a particular size form when the hyaluronic acid is a result of cross-linking. A carrier gel fluid made of non-cross-linked hyaluronic acid acts as a vehicle for these particles.

Since Belotero is non-particulate in nature, it will not clump. This allows it to produce very smooth outcomes when injected close to the skin’s surface.

Belotero’s continuous molecular structure prevents a common light refracting phenomenon, the Tyndall effect. The Tyndall effect results in a bluish tint on the skin. This occurs when light rays bend as they pass through a clear medium, such as one created through a Belotero procedure.

Belotero has given patients a reliable and long-awaited treatment option for addressing unwanted fine lines.

Manhattan Beach Patient Gets Belotero Treatment for Forehead Creases

Dr.U injected Belotero to fill the patient’s forehead creases. These were a result of years of raising her brows and furrowing her eyebrows together.

He injected Belotero right below the base of each of the fine line grooves. The filler worked to lift the crease upward, blending it in with the surrounding skin.

How Belotero works for forehead creases and other wrinkles. Image -

How Belotero works for forehead creases and other wrinkles. Image –


Treatment sessions using Belotero usually last around 30 minutes. Patients normally experience redness, swelling, and minor bruising after their procedure. These issues usually heal within a week.

Belotero’s double cross-linked structure creates a more substantial dermal filler that lasts longer without being metabolized. The effects of Belotero fade after a period of about twelve months.

Dr. U’s Medical Expertise for Belotero and Other Dermal Filler Procedures

As a board-certified dermatologist with extensive patient experience, Dr. U can provide effective, safe dermal filler procedures. They help individuals, like the patient shown here, look their very best while avoiding negative complications.

Belotero is a Frown Line Filler  Before and After

These before and after photos show the patient’s results at 3 weeks after Belotero following her procedure with Dr. U.

Forehead furrows are no longer apparent on the patient.*

Forehead furrows are no longer visible to the patient.*

Dr. U's treatment with Belotero for forehead wrinkles helped this patient look her absolute best.

Dr. U’s treatment with Belotero for forehead wrinkles helped this patient look her absolute best.*

She reported that other people noticed an improvement in her appearance, complimenting her on how young she looked, following her treatment.

Video of Dr. U’s Treatment with Belotero for Forehead Creases and Furrows

Watch this video as the patient gives an exuberant  “thumbs up for Dr. Umar.” Her Belotero treatment successfully resolved the fine lines on her forehead and brow area.

This Manhattan Beach, Los Angeles patient consulted Dr. U about Belotero for forehead wrinkles.

Speak to Dr.U about eliminating fine lines on the forehead by scheduling a free consultation with our office. Our convenient online consultation form will guide you through the process of making your appointment.

FAQ – Belotero for Forehead Lines and More

Can I use Botox and Belotero to get rid of frown lines?

Many doctors use Botox and Belotero together.  Although Botox relaxes muscles to prevent dynamic, mobile wrinkles, many patients also want to eliminate static etched lines on their skin.  Thanks to the availability of Belotero, these creases are easily dealt with.

Is it better to get rid of frown lines on the forehead with laser or Belotero?

Laser procedures can help the skin produce new collagen, which may resolve static frown lines on the forehead.  However, results are more unpredictable due to physiological differences across patients.  The doctor recommends more than one session, at the very least.

Belotero offers a more reliable solution for fine lines between the brows, forehead, and elsewhere on the face through a single treatment.

Besides forehead furrows, what other areas can Belotero treat?

Belotero is a viable way to fill in any fine line on the face.  Besides forehead furrow, it can fill in etched elevens between the brows and crow’s feet lines at the sides of the eyes. Also, Belotero can treat fine lines in the mid and lower facial regions, such as vertical smile lines and vertical lip lines.

Is it ok to get Belotero treatments for forehead lines and other wrinkles at a spa or salon? Also, is it safe to buy dermal fillers online? 

Every patient should seek a qualified professional when choosing a dermal filler or another type of injectable. Your chosen facility should be well-prepared to handle any potential emergencies should they arise.

Members of the American Academy of Dermatology have reported an increase in the number of patients requiring help for botched dermal filler results.

Filler injections require an in-depth understanding of nerves, blood vessels, and muscles. Vascular complications may arise due to injection mistakes. Blocking a blood vessel can cause blindness or strokes.  Other consequences may include allergic reactions and disfigurement.

Cosmetic fillers sold on the internet are illegal. Only licensed medical practitioners may acquire Belotero and other FDA-approved injectables.

The desire for results at an affordable price often drives these decisions. Buyers often risk spending thousands of dollars trying to fix disastrous outcomes.


For more information on Belotero and hyaluronic acid fillers in general, you can always contact Dr. U through our Ask Dr. U online form:



  1. Gauglitz, Gerd et al. “Cohesive Polydensified Matrix® hyaluronic acid volumizer injected for cheek augmentation has additional positive effect on nasolabial folds.” Clinical, cosmetic and investigational dermatology vol. 10 507-513. 14 Dec. 2017

Further Reading

Learn more about Dr. U’s patient, who treated his crow’s feet with Belotero instead of Botox.

See how this patient of Dr. U addressed an unwanted smile line on her face using Belotero.